I am an Assistant Professor of Emergency Medicine at Harvard Medical School and Director of the Translational Research Unit at Emergency Medicine Network, Department of Emergency Medicine, Massachusetts General Hospital. I did my post-doctoral fellowship at Harvard T.H.Chan School of Public Health and Massachusetts General Hospital. Before my post-doctoral fellowship, I received doctoral of science degree in Environmental and Molecular Epidemiology at Harvard T.H.Chan School of Public Health and bachelor of science degree in Biomedical Engineering from Case Western Reserve University.

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My research interests mainly include identifying the biological risk factors for respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS) using multi-omics data, such as genome-wide association study (GWAS), transcriptomics, proteomics, metabolomics, epigenomics, and microbiome, and I hope to transform the research findings into community prevention and clinical intervention.

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Google Scholar: https://scholar.google.com/citations?user=tNNSr6YAAAAJ&hl=en&oi=ao

Harvard Catalyst: https://connects.catalyst.harvard.edu/Profiles/display/Person/99489

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Selected publications:

Zhu Z, Lee PH, Chaffin MD, Chung W, Loh P-R, Lu Q, Christiani DC, Liang L. A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nature Genetics 2018;50(6):857-864.

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Zhu Z, Shibata R, Hoffman KL, Cormier J, Mansbach JM, Liang L, Camargo CA, Hasegawa K. Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma. European Respiratory Journal 2024;64(6):2401130.

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Zhu Z, Li Y, Freishtat RJ, Celedón JC, Espinola JA, Harmon B, Hahn A, Camargo CA Jr, Liang L, Hasegawa K. Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study. Nature Communications 2023;14(1):5495.

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Zhu Z, Freishtat RJ, Harmon B, Hahn A, Teach SJ, Pérez-Losada M, Hasegawa K, Camargo CA Jr; MARC-35 Investigators. Nasal airway microRNA profiling of infants with severe bronchiolitis and risk of childhood asthma: a multicentre prospective study. European Respiratory Journal 2023;62(2):2300502.

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Zhu Z, Camargo CA Jr, Raita Y, Freishtat RJ, Fujiogi M, Hahn A, Mansbach JM, Spergel JM, Pérez-Losada M, Hasegawa K. Nasopharyngeal airway dual-transcriptome of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study. Journal of Allergy and Clinical Immunology 2022;150(4):806-816.

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Zhu Z, Camargo CA Jr, Raita Y, Fujiogi M, Liang L, Rhee EP, Woodruff PG, Hasegawa K. Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma. Journal of Allergy and Clinical Immunology 2022;149(1):102-112.

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Zhu Z, Li J, Si J, Ma B, Shi H, Lv J, Cao W, Guo Y, Millwood IY, Walters RG, Lin K, Yang L, Chen Y, Du H, Yu B, Hasegawa K, Camargo CA Jr, Moffatt MF, Cookson WOC, Chen J, Chen Z, Li L, Yu C, Liang L. A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic etiology with obesity. European Respiratory Journal 2021;58(4):2100199.

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Zhu Z, Hasegawa K, Camargo CA Jr, Liang L. Investigating asthma heterogeneity through shared and distinct genetics: insights from genome-wide cross-trait analysis. Journal of Allergy and Clinical Immunology 2021;147(3):796-807.

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Zhu Z, Hasegawa K, Ma B, Fujiogi M, Camargo CA Jr, Liang L. Association of asthma and its genetic predisposition with the risk of severe COVID-19. Journal of Allergy and Clinical Immunology 2020;146(2):327-329.e4.

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Zhu Z, Hasegawa K, Ma B, Fujiogi M, Camargo CA Jr, Liang L. Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data. Metabolism 2020;112:154345.

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Zhu Z, Guo Y, Shi H, Liu CL, Panganiban RA, Chung W, O’Connor LJ, Himes BE, Gazal S, Hasegawa K, Camargo CA Jr., Qi L, Moffatt MF, Hu FB, Lu Q, Cookson WOC, Liang L. Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. Journal of Allergy and Clinical Immunology 2020;145(2):537-549.

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Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K, Camargo CA Jr., Liang L. Shared Genetics of Asthma and Mental Health Disorders: A Large-Scale Genome-Wide Cross-Trait Analysis. European Respiratory Journal 2019;54(6).

 

Zhu Z, Camargo CA Jr., Hasegawa K. Metabolomics in the prevention and management of asthma. Expert Review of Respiratory Medicine 2019;13(12):1135-1138.

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Zhu Z, Lin Y, Li X, Driver JA, Liang L, Shared genetic architecture between metabolic traits and Alzheimer’s disease: A large-scale genome-wide cross-trait analysis. Human Genetics 2019;138(3):271-285.

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Zhu Z, Wang X, Li X, Lin Y, Shen S, Liu CL, Hobbs BD, Hasegawa K, Liang L, Boezen HM, Camargo CA Jr, Cho MH, Christiani DC. Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: A large-scale genome-wide cross-trait analysis. Respiratory Research 2019;20(1):64.

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Zhu Z, Zhang R, Liang L, Su L, Lu Q, Baccarelli AA, Bajwa EK, Thompson BT, Christiani DC. Whole blood microRNAs as a prognostic classifier for acute respiratory distress syndrome 28-day mortality. Intensive Care Medicine 2016;42(11):1824-1825.​

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Lee PH, Anttila V, Won H, Feng YCA, Rosenthal J, Zhu Z (6th of 606 authors), …, Smoller JW. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell 2019;179(7):1469-1482.e11.